Dang nobody answered. Okay, first off, have you done any handloading before? By the "get started" part of your post I will assume not.
First thing would be a reloading manual, like the Speer book. You will need at the very least, a single stage press, a set of dies, a primer tool, a powder measure, some new unprimed brass cases, some primers, some powder, and some bullets.
That is about the bare essentials needed to begin assembling handloads from new components.
You need to read read read read and read some more. Handloading is cool, saves you money (or it USED TO!) lets you build hunting and target loads you can't buy off store shelves, but it is a complex art, and VERY dangerous. There is a lot to it really.
The MOST important thing for YOU to remain conscious of, is that you have two fine Ruger revolvers, but your New Vaquero CANNOT handle the same max loads that the Old Vaquero can handle! It's cylinder is smaller and thinner, it's frame is smaller, and it will not be safe with the "Ruger ONLY" loads that you will find in the reloading books, and also in countless magazine articles and various online sources.
I reloaded and handloaded for years and years and of all the calibers I had my bench set up for, .45 Colt is by far my favorite to handload for, and my favorite to shoot and also to hunt with. There is nothing on the North American continent that the .45 Colt won't do, and that includes target shooting, cowboy action shooting, and taking of any big game or dangerous animal that we are likely to encounter. Even in it's original 1873 black powder loading, it is a more powerful and more effective combat/self defense round than the .45 ACP, .44 Special, and the .38 Special.
Although I based my load development on data contained in the Speer manual, I found a lot of the gun press articles from reputable writers such as John Taffin, Mike Venturino, Phil Spangenberger and others who shared their own favorite loads and data for the .45 Colt to be accurate, safe, and very enjoyable to load and shoot.