taurean, 38 Special 148 gr LHBWC = low sound level, minimal recoil, very accurate, won't penetrate walls, minimal muzzle flash, creates a large wound channel. When you get 10 posts or more, take a look at the short article I wrote in the Library; "Preparation for Home Protection".
I seem to rotate mine depending upon mood or while cleaning what was shot at the range; let's run through the list...
the one that is the most frequent is my S&W 642 snubby w/ Remington 158gr lswchp .38 +p's (my primary CCW piece...grab the pocket holster, place the 642 inside it and into a pocket, and follow that with a Bianchi Speed Strip (same load) into a back pocket; when not doing CCW, it stays in a drawer in the night stand;
I like to have a 'full sized' house gun as the primary...right now it is my blued Ruger Security Six w/ 4" barrel (same FBI load as snubby); sometimes a Glock 17 w/ either Winchester WWB Personal Defense 147gr jhp's or Remington UMC 115gr jhp's in 9mm; when I feel like going really 'old school' I'll grab my Uberti Colt 1873 SAA clone w/ 4" barrel and load it w/ Blazer (aluminum case) 200gr jhp (Speer Gold Dot) or Federal's 225gr lswchp in .45 Colt;
the next 2 are rare due to size & weight: 1) S&W 629 PowerPort w/ Hornady XTP 180gr jhp's in .44 spl or 2) stainless Ruger Blackhawk w/ 6.5" barrel loaded with Remington FBI load (.38 spl +p)
I keep a Ruger SP101 3" with 125 gr SJHP in .38 spl. I also keep others there such as a Taurus M85 (38), G22 .40 and also my G27. It really depends on if I'm working or not, but the Ruger stays always.