Not really enough info, are you already an accomplished shooter? Are you recoil shy? etc, etc, .
So here goes,,,
As feralcatkiller said, my wife also tried the sr22. Not only was is a defective pistol that Ruger took back, she hated it. And justifyibly so. HArd and confusing for a beginner, jammed constanly, and sprayed lead all over the place. A piece of junk IMO. And I wouldnt recommend anyone carry a 22 long rifle for personal protection. The ammo is undependable IMO, for more reasons than one.
So her first real conceal carry was a LCR 22 mag. She learned on it, and loves it to this day. Very easy to learn to clean, handle, load. Very concealable. You can pocket carry it. Nothing to snag. She made it VERY clear when I offered to get her a 9mm, that she wanted to keep the LCR 22mag. And 22 mag aint nothing to sneeze at anyway. They have more penetration than a .38, and will blow right through kevlar and most body armor. I seen a 22 mag in a derringer drop a 300 lb body builder type who was charging the guy, right in his tracks. HHit him in the chest. All he could do was lay and moan until the ambulance hauled him off. He was in the hospital for about 2 or 3 months. They are also VERY, VERY accurate. With no recoil, rapid follow up shots are easy. And in a high stress situation, its point and pull. And its NOT going bang, unless YOU make it go bang. So very safe. I would recommend adding a GREEN night sight. ( about $25.) The green sight makes a nice little revolver, a great little revolver. And ammo wise, in a 1000 round case of CCI maxi mag in 22 mag, I think Ive had one ammo failure with a dud primer. So pretty dependable. LCR 22 mag, About $425.
Her " gradutaion pistol was a 9mm CZ Rami 2075D. Thats a decocker model with no safety. Also, VERY VERY safe to carry and easy to conceal. Again, its NOT going bang, unless you make it go bang. Very low recoil for a 9mm that small, and very accurate. Comes with combat night sights which are really good, . And like the LCR, point and pull. And as with all the CZ stuff Ive owned, they are well known for accuracy and dependability, just a damn fine weapon all around. She also love it. $625.
I personally love and carry the 9mm CZ 75 PCR, also a decocker. A little bigger than the Rami, but still very concealable. Pcr comes with tritium night sights, mine came with combat night sights. The CZ 75 P01 is also the same size,a decocker, and has a rail, but the sights are not very good. Both are excellent sidearms. With factory rubber grips, they fit your hand like a good glove. Awesome ergonomics. The PCR runs about $525, the P01 runs about $575.
My PCR has about 1500 rounds of CCI Blazer brass fired, no failures of any kind. My wife also like shooting both, just a hair to big for her to conceal in her line of work.
Any CZ 75 series pistol can be sight upgraded with TruGlo TFX night sights, which are awesome. They glow brightly in total blackness, have a 25 yards POA / POI with a 6 oclock hold. About $100. All my CZ 75 series have them.
I personally DONT care for the cocked and locked carry, but I will give a shout out to the 9mm Sig, 938 black widow. My daughter in law has one. Ive shot it. Very small, low recoil, perfect function, and VERY accurate. Comes with really good tritium night sights. I think they are over $700.
Several good things about 9mm, its cheap, its accurate, and it has plenty of stopping power. I get 1000 round cases of CCI blazer brass for about $225. And during an "ammo scare/shortage", you can ALWAYS find 9mm.
And just so I dont get accused of sounding sexist, If you can carry it, I personally recommend an M2 Quad fiftie. NOT the easiest to conceal, but It will stop an armored vehicle in its tracks, kill houses, and take out taliban @ OVER 2500 yards. And you only gotta hit em ONCE.